As Asia faces unprecedented demographic transitions alongside climate change impacts, vulnerable populations—including aging communities, migrant workers, and youth in rapidly urbanizing areas—bear disproportionate health burdens. The intersection of demographic shifts, climate pressures, and health system constraints demands innovative, scalable solutions that address both immediate adaptation needs and long-term resilience building. This side meeting brings together the Asia Health Leaders Coalition for Sustainable and Resilient Health Systems to bridge the gap between proven interventions and system-wide transformation.